CSL Plasma O'Fallon, IL

Donating at CSL Plasma O'Fallon, IL

CSL Plasma O'Fallon, IL is a CSL Plasma donation center at 2025 W Hwy 50 in O'Fallon, IL. You can reach it on 618-726-0339. It opens 6 days a week — check the table for the day you plan to visit.

Who can donate here

CSL Plasma asks that you are between 18 and 69 and you weigh at least 110 lb. You will also need photo ID, proof of your Social Security number, and proof of your current address. A tattoo or piercing in the last 4 months means waiting before you can donate.

When it is open

This location opens 6 days a week, closed Sun. Across the week the doors are open from 7am at the earliest to 6pm at the latest. Check the table above for the exact day you plan to visit. Returning donors can usually walk in, but a first visit is best booked ahead.

Your first visit

later visits typically run about 90 minutes. CSL Plasma pays onto a prepaid debit card, usually within a few hours of you finishing.

Before you go

Drink plenty of water and eat a full meal in the few hours beforehand. Low iron and dehydration are the two most common reasons people are turned away on the day. Avoid alcohol for 24 hours and fatty food on the day itself. Hours and requirements are set locally and do change, so it is worth a quick call before you travel.

Where this fits

See also all plasma centers in O'Fallon, Illinois directory and all CSL Plasma locations.

Location details verified against PlasmaLedger's directory on 2026-09-01. Confirm hours with the center before travelling.